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Mostrando ítems 1-7 de 7

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      Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

      García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
      Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative 

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
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      Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus 

      Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023)
      Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
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      Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis 

      Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Fernández Valenzuela, Juan José; Castro, Vanessa de; Mejías Ortega, Marina; Gómez Arboledas, Ángela; Jiménez, Sebastián; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Frontiers Media, 2021)
      Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
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      Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice 

      Larramona Arcas, Raquel; González Arias, Candela; Perea, Gertrudis; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; García Barrera, Tamara; Gómez Ariza, José Luis; Pascua Maestro, Raquel; Ganfornina, María Dolores; Kara, Eleanna; Martínez Vicente, Marta (BMC, 2020)
      Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ...
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      Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
      Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration 

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel María; Núñez Díaz, Cristina; Trujillo Estrada, Laura Isabel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...